By Denny Basens, Sports Talk Philly staff writer 
Buffalo at Cincinnati
Marvin Lewis is well on his way to being fired with his team's continued struggles.
Pick: Buffalo 23, Cincinnati 20
Pittsburgh at Cleveland
After dropping two straight, this is a must-win situation for the Steelers. The Browns inch ever closer towards 0-16 infamy.
Pick: Pittsburgh 30, Cleveland 13
Baltimore at Dallas
The Cowboys have looked damn near unbeatable. They're finding ways to win, and taking out good teams along the way. Until they finally drop a game, you can't pick against them.
Pick: Dallas 31, Baltimore 20
Jacksonville at Detroit
The Lions have a great matchup at home against one of the league's most disappointing teams.
Pick: Detroit 24, Jacksonville 16
Tennessee at Indianapolis
Who would have thought both of these teams were capable of beating Green Bay? The Colts are fresh off of the bye, this is a week where I think Andrew Luck carries them to a win.
Pick: Indianapolis 27, Tennessee 23
Tampa Bay at Kansas City
The Chiefs should find a way to win at home against a talented but inconsistent Tampa team.
Pick: Kansas City 24, Tampa Bay 20
Arizona at Minnesota
The Vikings continue to sink into the abyss.
Pick: Arizona 20, Minnesota 13
Chicago at New York
The Bears look like a dead, defeated football team. The Giants should roll at home.
Pick: New York 30, Chicago 10
Miami at Los Angeles
The Rams finally turn to Jared Goff. Expect rookie struggles and mistakes, and another win for Miami, who has quietly been playing very well of late.
Pick: Miami 17, Los Angeles 10
Philadelphia at Seattle
Very difficult matchup on the road against one of the NFC's best likely spells a loss for the young and offensively limited Eagles.
Pick: Seattle 23, Philadelphia 17
New England at San Francisco
Another week, another blowout loss for Chip Kelly, who is now just 8-20 in the NFL after starting 19-9.
Pick: New England 38, San Francisco 13
Green Bay at Washington
This is the week that Aaron Rodgers and the Packers get themselves right and snap their losing streak.
Pick: Green Bay 31, Washington 28
Houston at Oakland
The Texans' pitiful offense won't be able to overcome the young, surprising Raiders on the road.
Pick: Oakland 27, Houston 13
